Lipitor or atrovastatin, is the best selling medication because it is a fairly effective reducer of cholesterol levels.  Considering the role cholesterol plays in heart disease, the largest cause of death in the United States, reducing its levels may lead to better health in the long run.

As such, many millions of prescriptions have been filled for Lipitor.  It is a fairly safe and mild drug.  Because it doesn’t have a dramatic impact, the vast majority of people who take it don’t stop due to adverse reactions – less than 3% do.

That said, because it is so widely used, Lipitor has unusual side effects that only happen because of its popularity.  Among those, one of the most feared is Rhabdomyolysis, a condition where your body launches an attack against itself, with 10% mortality.  Thankfully, it is quite rare.

As follows, are the side effects of Lipitor, with a focus on the ones that are unusual or rare.

Most common:

Stomach upsets, including nausea. Flatulence, constipation. Elevations in some liver associated enzymes.

Due to potential damage to the baby, women who are pregnant should not take Lipitor.

General issues:

Possible slight increase in rates of insomnia.  That same analysis showed long term use of Lipitor may also be associated with slightly less rates of confusion, so take it as you will.

The potential of Lipitor to cause cancer is highly debated.  Most argue there is no risk, and point to many supporting studies, but in rat models, hepatic tumors were shown to be caused by statin treatment.

Rare side effects of Lipitor:

Hypersensitivity reactions: your body develops an immune response because of the medication and starts attacking itself.  This can manifest itself in skin conditions, rashes, hypotension or other.  One estimate of hypersensitivity reactions put incidence as high as 0.1% – or 1/1,000.

Cholestatic jaundice: your skin turns yellow due to deposition of bile

Rhabdomyolysis: quite rare but serious.  For every 100,000 people taking Lipitor over a year, 3 will experience this.  May be exacerbated by combining treatment with other medications including fibrates

Liver failure: while also quite rare, serious

Interstital lung disease: some case reports have indicated the potential of Lipitor to be associated with hypersensitivity and lung issues

Confusion, paranoia:  An elderly woman developed confusion and paranoia shortly after starting treatment.  After two months, she stopped the medication and four days later, was back to normal.

Testicular pain

Erectile dysfunction

Gynecomastia: a man switched from another statin onto Lipitor, and soon after started developing breast tissue.  The medication was a probable cause.

Tendon problems, like tendonitis and pain

Hemorrhagic stroke is reported at higher rates in people with lower levels of cholesterol, which may be caused by high doses of statins.

Peripheral neuropathy or nerve damage in certain parts of the body

Remember, some of these symptoms are extremely rare.  We report them to provide an overview of some of lipitor’s unsual side effects.

Do you have a strange side effect from Lipitor?

Billion dollar lawsuits, scientists on drug company payrolls, and endless advertising.  The ten best selling medications in the US tell quite the story.  Without further ado…

#1 Lipitor

Lipitor, a treatment for high cholesterol, comes in at number one.  Can you guess how much it makes Pfizer every year?

What it does: Lipitor works by inhibiting an enzyme in the cholesterol synthesis pathway.  So take it, and you make less cholesterol.

This is important because cholesterol tends to stick to our arteries like gum to a lead pipe, clogging them up.  Which is bad.

Concerns:  While fighting cholesterol is typically a good thing, Lipitor is part of a trend towards medicine that is very statistically based.  You may be perfectly healthy, but studies show that taking this pill will reduce your chance of ABC by XYZ, so go ahead and take it.

That’s good, right?  Well, scientists are far from perfect.  And, we’ve discussed how the cholesterol level deciding committee is essentially entirely on the payroll of big pharma.  The guys who decide how much medicine you should take are paid by the companies which make drugs.  Not so good.

The weird stuff: Pfizer used Dr. Jarvik in many Lipitor advertisements, but accidentally forgot to mention that he wasn’t actually a medical doctor.  (But since he did invent the first artificial heart, personally, I think he knows what he’s talking about!)

Sales: $13 billion annually

#2 Plavix

Plavix – my professor calls it a “wonder drug.”  Why?  I’m not entirely clear, but it certainly is popular.

What it does:  Plavix makes blood platelets less likely to form a clot.  Technically, it binds to a receptor for ADP and blocks it, which stops an important signaling pathway.  Since clots can be deadly (what do you think happens when a large piece of gunk clogs up your heart?), that’s a good thing.

It’s mostly used in the context of a heart attack.  Remember, that heart disease is the number one killer in the US by far, which explains its popularity.

Concerns:  Heavy marketing towards consumers.  The ads pretty much say that you’ll die if you don’t take Plavix.  Considering that it has serious side effects, and that it should only be used in certain types of heart attack, that’s a bad thing.

Plavix is the type of nitty-gritty drug that you should expect your doctor to know about.  And when you’re being put in an ambulance to the ER with a heart attack, the last thing you should have to think about is an ad on TV telling you that you’ll die unless your doctor gives you a specific drug.

Sales: $6 billion

#3 Advair

What it does: Advair relaxes the lungs and reduces inflammation there, mainly used for asthma.  Chemically, it’s a combination of a steroid (which reduces swelling) and a long acting beta agonist (which tells your lungs to relax).

The weird stuff:  Advair has a black box warning.  That’s the worst that can happen to a drug short of being pulled off the market.  The reason?  One of its ingredients was shown to increase your risk of dying from asthma by 400%!

(You can read why Advair is probably a safe drug.  But still scary.)

Sales: $6 billion

#4 Nexium

Aka, “The Purple Pill.”

What it does: Nexium interferes with a proton pump in the stomach.  Proton pumps are responsible for establishing concentrations of hydrogen that are acidic.  Nexium, thus, reduces acid secretion in the stomach.

Considering how common indigestion and stomach pain is, it’s quite popular.

The downsides:  Nexium is an expensive prescription drug.  What it consists of, however, is nothing more than a specific form of the active ingredient in a much cheaper drug.  Is it any better than the cheaper form?

Sales: $5 billion

#5 Norvasc

What it is used for: Heart pain and hypertension

What it does:  Norvasc blocks calcium channels.  Because calcium is an essential chemical in muscle contractions, blocking calcium channels can lead to muscular relaxation.  Muscle relaxation can lead to improved blood flow and lower blood pressure.

3 Weird Side Effects:

1) Norvasc can make certain types of your white blood immune cells go bye bye
2) It can make your gums start growing, elegantly named gingival hyperplasia.
3) Stasis dermatitis.  Blood in your legs starts pooling up, possibly popping capillaries.  Your skin can turn brown.

These are quite rare, however.

Sales: $4.8 billion

#6 Zyprexa

What it’s used for:  Schizophrenia and bipolar disorder.

The naughty stuff:  Eli Lilly, the company which makes Zyprexa, covered up the drug’s serious side effects like increased risk of diabetes.  They also pushed the drug to be used for many conditions which it was never shown to work, like senile dementia.

So the executives at Eli Lilly were fine with Grandma being put on a powerful anti-psychotic that could cause diabetes, uncontrolled movement disorders, and dizziness just so they could make more money.

Their highly unethical marketing cost them a $1.4 billion lawsuit.

If you want to learn more about Zyprexa, I’d highly recommend checking out Furious Seasons, an investigative blog that covers it and other BigPharma shenanigans.

Sales: $4.3 billion

#7 Risperdal

We’ve talked about Risperdal before.  A popular, tranquilizing antipsychotic.

What it’s used for:  Everything.  See a shrink?  You might get given Risperdal.  It’s that simple.

The bad stuff:  An antipsychotic with serious side effects is being used for every single psychiatric ailment.  Don’t believe me?

OK.  Off the top of my head, Risperdal is used for ADHD, anxiety disorders, depression, schizophrenia, bipolar disorder, OCD, dementia, autism, and eating disorders.

And that’s without checking for the endless papers with titles like, “Risperidone may show efficacy for treating shoe-eating zombies.”

But don’t worry.  Shrinks know what they’re doing, and never get compensation from drug companies for making the right choices.

Sales: $4.1 billion

#8 Effexor

What it does: Makes people feel happy, except when it makes them suicidal, that is.  Chemically, Effexor inhibits reuptake of serotonin and norepinephrine.  This may help reduce anxiety and may play a role in treating depression.

The weird stuff:  While a treatment for depression, like many other antidepressants, Effexor may increase your risk of committing suicide.

Why is it that antidepressants can cause suicidal thinking and behavior?  Dunno.  More importantly, has that stopped more than 25% of students at some colleges from taking them?  Nope!

Sales: $3.7 billion

#9 Prevacid

What it does:  A proton pump inhibitor that…wait a second, it’s basically Nexium all over again.

Next!

Sales: $3.5 billion

#10 Zocor

What it does: Like Lipitor, Zocor is a statin, and is used to lower cholesterol levels.  To spice things up…

3 Weird Side Effects:

1) Zocor can cause dermatomyositis, a type of degenerative rash, where your immune system attacks the skin
2) It can also cause chylothorx, where the body leaks fluid into the space around the lungs
3) And it can cause your body to attack the kidneys causing, well, kidney failure

Note: these side effects also apply to Lipitor.

Sales: $3 billion